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Drug release properties of polymer coated ion-exchange resin complexes: experimental and theoretical evaluation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jeong, Seong Hoon Berhane, Nahor Haddish Haghighi, Kamyar |
| Copyright Year | 2007 |
| Abstract | Although ion-exchange resins have been used widely as drug delivery systems, their exact release kinetics has not been reported yet. Usually only the rate-limiting step has been taken into account and the rest of the steps have been ignored as instantaneous processes. To investigate the exact release kinetics of polymer-coated drug/ion-exchange resin complexes for sustained drug delivery, the results of new mathematical modeling were compared with experimental results. Drug/resin complexes with a model drug, dextromethorphan, were prepared and used as cores for fluid-bed coating. An aqueous colloidal dispersion of poly(vinyl acetate) was applied for the coating. A comprehensive mathematical model was developed using a mechanistic approach by considering diffusion, swelling, and ion-exchange processes solved by numerical techniques. The rate-limiting factor of the uncoated resin particles was diffusion through the core matrix. Similarly, in the coated particles the rate-limiting factor was diffusion through the coating membrane. The mathematical model has captured the phenomena observed during experimental evaluations and the release dynamics from uncoated and coated (at different coat levels) particles were predicted accurately (maximum RMSE 2.4%). The mathematical model is a useful tool to theoretically evaluate the drug release properties from coated ion-exchange complexes thus can be used for design purposes. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://web.ics.purdue.edu/~kpark/Published%20Papers/Jeong%2007%20JPharmSci.pdf |
| Alternate Webpage(s) | http://www.kinam.com/Articles/FDT%20Papers/Jeong%2006%20JPS.pdf |
| PubMed reference number | 17080409v1 |
| Volume Number | 96 |
| Issue Number | 3 |
| Journal | Journal of pharmaceutical sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Boyd Body Surface Area Formula Coating Excipient Dextromethorphan Diphenhydramine Hydrochloride 20 MG/ML / Zinc Acetate 1 MG/ML Topical Cream Drug Delivery Systems Drug Liberation Edema Evaluation Ions Iontophoresis Kinetics (discipline) Mathematical Concepts Mathematics Oral Pellet Polymers Resins, Plant Tissue membrane decimeter |
| Content Type | Text |
| Resource Type | Article |
