T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice

Content Provider	Semantic Scholar
Author	Bourdette, Dennis N. Vandenbark, Arthur A. Hashim, George Whitham, Ruth H. Offner, Halina
Copyright Year	1989
Abstract	T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99. These lines transferred a demyelinating and chronic relapsing form of experimental autoimmune encephalomyelitis (EAE) into naive mice, and EAE induced by synthetic peptide-derived lines was more severe than that induced by whole BP-derived lines. This study demonstrates that T cell lines selected with synthetic peptides are encephalitogenic in SJL/J mice and offers an improved means for selecting SJL/J encephalitogenic T cell lines.
Starting Page	255
Ending Page	260
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	2467920
Journal	Medline
Volume Number	22
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0165572889900234
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0165572889900234?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0165-5728%2889%2990023-4
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article