NDLI: Effects of resveratrol on the Nrf 2 and HO-1 expression in diabetic vascular endothelial cells

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Effects of resveratrol on the Nrf 2 and HO-1 expression in diabetic vascular endothelial cells

Content Provider	Semantic Scholar
Author	Wang, Lingxiao
Copyright Year	2016
Abstract	Oxidative stress plays an important role in the pathogenesis of diabetes. High concentration of glucose can increase the generation of reactive oxygen species (ROS). Excessive generation of ROS can activate multiple signaling pathways of vascular disease, resulting in the damage of cells. Herein we aim to characterize the protective effect of resveratrol on diabetic rat vascular endothelium, and to investigate the influence of resveratrol on retinal nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) genes, which are associated with elimination of ROS. In diabetic rat, body weight, blood lipid, blood glucose, capillaries density, basement membrane thickness and ratio of capillaries to muscle fibers were examined. Levels of transcripts and protein expression of Nrf2 and HO-1 genes in retinal tissue were detected by fluorescence quantitative PCR, Western blot and immunohistochemistry. Our results showed that resveratrol significantly decreased the concentration of blood glucose and triglycerides, and largely increased body weight and capillaries density. In addition, in our study the levels of transcripts and translation of Nrf2 and HO-1 genes gradually returned to normal from high points. In conclusion, resveratrol can decrease blood glucose, blood lipid and protect vascular endothelial cells from injury caused by diabetes, and can regulate the Nrf2/HO-1 pathway, which is firmly related to maintain redox state balance of retina.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijcem.com/files/ijcem0019905.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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