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Review of Cytology Practice at Thomas Jefferson University Hospital before and after High-Risk Human Papillomavirus Testing
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bibbo, Marluce Wang, Zi-Xuan Jones, Krister Solomides, Charalambos C. Draganova-Tacheva, Rossitza Stapp, Robert |
| Copyright Year | 2016 |
| Abstract | Objective: We performed a retrospective review of Papanicolaou (Pap) testing to assess whether the cytology practice in our institution was affected by the introduction of high-risk (HR) human papillomavirus (HPV) assays over time. Study Design: Cytology, HPV and histopathology records were retrieved from our laboratory information system from 2003 to 2015. Records for Digene Hybrid Capture 2®, Hologic Cervista® and Roche Cobas® HPV assays were obtained. A 3-month follow-up for HPV detected cases was performed, and results were correlated with cytology and biopsies. A 1-year follow-up of HPV 16/18 and other HR HPV detected cases was also performed. Results: From 2008 to 2015, a noticeable decrease in Pap testing volume occurred, from 11,792 to 4,664, while the percentage of HPV testing increased from 19 to 59%. Similar HPV detection rates and follow-up results for both reflex and cotesting were observed in the 3 HPV assays. Conclusions: The decrease in Pap testing was due to the lengthening of the test interval when cotesting results were negative. Practitioners adhering to guidelines accounts for increased molecular testing volume. A trend towards higher-grade cervical intraepithelial neoplasia in the follow-up of detected HPV 16/18 was noted. So far there has been no demand for HPV as a stand-alone test. |
| Starting Page | 534 |
| Ending Page | 539 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1159/000446271 |
| PubMed reference number | 27245463 |
| Journal | Medline |
| Volume Number | 60 |
| Alternate Webpage(s) | https://www.karger.com/Article/Pdf/446271 |
| Alternate Webpage(s) | https://doi.org/10.1159/000446271 |
| Journal | Acta Cytologica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
