NDLI: Intensity modulation of TMS-induced cortical excitation: primary motor cortex.

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Intensity modulation of TMS-induced cortical excitation: primary motor cortex.

Content Provider	Semantic Scholar
Author	Narayana, Shalini Tandon, Nitin Sandoval, Hugo Capaday, Charles
Copyright Year	2006
Abstract	The intensity dependence of the local and remote effects of transcranial magnetic stimulation (TMS) on human motor cortex was characterized using positron-emission tomography (PET) measurements of regional blood flow (BF) and concurrent electromyographic (EMG) measurements of the motor-evoked potential (MEP). Twelve normal volunteers were studied by applying 3 Hz TMS to the hand region of primary motor cortex (M1(hand)). Three stimulation intensities were used: 75%, 100%, and 125% of the motor threshold (MT). MEP amplitude increased nonlinearly with increasing stimulus intensity. The rate of rise in MEP amplitude was greater above MT than below. The hemodynamic response in M1(hand) was an increase in BF. Hemodynamic variables quantified for M1(hand) included value-normalized counts (VNC), intensity (z-score), and extent (mm(3)). All three hemodynamic response variables increased nonlinearly with stimulus intensity, closely mirroring the MEP intensity-response function. VNC was the hemodynamic response variable which showed the most significant effect of TMS intensity. VNC correlated strongly with MEP amplitude, both within and between subjects. Remote regions showed varying patterns of intensity response, which we interpret as reflecting varying levels of neuronal excitability and/or functional coupling in the conditions studied.
File Format	PDF HTM / HTML
PubMed reference number	16161021v1
Volume Number	27
Issue Number	6
Journal	Human brain mapping
Language	English
Access Restriction	Open
Subject Keyword	Area striata structure Cerebral cortex Excitation Hemodynamics Hertz (Hz) Motor Neuron Disease Positron-Emission Tomography Positrons Regional Blood Flow Transcranial magnetic stimulation
Content Type	Text
Resource Type	Article

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