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Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

Content Provider	Semantic Scholar
Author	Fidler, Aaron L. Darris, Carl Chetyrkin, Sergei V. Pedchenko, Vadim K. Boudko, Sergei P. Brown, Kyle L. Jerome, W. Gray Hudson, Julie K. Rokas, Antonis Hudson, Billy G.
Copyright Year	2017
Abstract	The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collagens, of non-bilaterian animal phyla. We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and Bilateria. Yet, ctenophore features are more diverse and distinct, expressing up to twenty genes compared to six in vertebrates. Moreover, collagen IV is absent in unicellular sister-groups. Collectively, we conclude that collagen IV and its variant, spongin, are primordial components of the extracellular microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental architectural unit for multicellular tissue genesis.
Starting Page	R836
Ending Page	R837
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMjQxNzYvZWxpZmUtMjQxNzYtZmlndXJlcy12MS5wZGY=/elife-24176-figures-v1.pdf?_hash=kwPbj%2BkoeJ9of1GBgzVelw4cpB8vIXUnjnzeiYh1Ifs%3D
Alternate Webpage(s)	https://s3.amazonaws.com/vu-wp0/wp-content/uploads/sites/191/2017/04/18133007/2017_Fidler_etal_eLife.pdf
PubMed reference number	28418331
Alternate Webpage(s)	https://doi.org/10.7554/eLife.24176
DOI	10.7554/elife.24176
Journal	eLife
Volume Number	6
Language	English
Access Restriction	Open
Subject Keyword	Basement membrane Bilateria Body tissue Cellular Microenvironment Collagen Type IV Ctenophora Ctenophora Extracellular Matrix Genomics Non-Fibrillar Collagens Vertebrates negative regulation of type IV pilus biogenesis
Content Type	Text
Resource Type	Article

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Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

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Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

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Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

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Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues