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Monitoring oxygen concentration during photodynamic therapy using prompt photosensitizer fluorescence.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Weston, Mark A. Patterson, Michael S. |
| Copyright Year | 2013 |
| Abstract | A novel technique is described that uses either time-resolved or steady state prompt photosensitizer fluorescence to measure local oxygen concentration. Solution experiments conducted with Al(III) phthalocyanine chloride tetrasulfonic acid confirmed that the steady state fluorescence signal is dependent on the oxygen concentration and fluence rate. A relationship between prompt sensitizer fluorescence and sensitizer triplet quenching efficiency is derived which does not require knowledge of the Stern-Volmer constant. Similar relationships are also derived for sensitizer delayed fluorescence and phosphorescence. An explicit photodynamic therapy (PDT) dose metric that incorporates light dosimetry, sensitizer dosimetry, and triplet quenching efficiency is introduced. All components of this metric can be determined by optical measurements. |
| Starting Page | 391 |
| Ending Page | 391 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://iopscience.iop.org/article/10.1088/0031-9155/58/20/7039/pdf |
| PubMed reference number | 24051952v1 |
| Alternate Webpage(s) | https://doi.org/10.1088/0031-9155/58/20/7039 |
| DOI | 10.1088/0031-9155/58/20/7039 |
| Journal | Physics in medicine and biology |
| Volume Number | 58 |
| Issue Number | 20 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Chloride Ion Fluorescence Large Light Dosimetry Oxygen Phosphorescence Photochemotherapy Radiometry Radiotherapy Planning, Computer-Assisted Singlet Oxygen Thioctic Acid aluminum tetrasulfophthalocyanine |
| Content Type | Text |
| Resource Type | Article |
