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Preparation and Release Property of Alginate Beads Immobilizing Poly(N-isopropylacrylamide-co-dimethylamino ethyl methacrylate)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kang, Mi Kyoung Kim, Jin Chul |
| Copyright Year | 2010 |
| Abstract | Alginate beads were prepared using poly(N-isopropylacrylamide-co-dimethylamino ethyl methacrylate)(P(NIPAM-co-DMAEMA)). First, P(NIPAM-co-DMAEMA) was immobilized on the surface of alginate beads by taking advantage of electrostatic interaction between alginate and P(NIPAM-co-DMAEMA). Second, P(NIPAM-co-DMAEMA) was contained in the matrix of alginate beads. P(NIPAM-co-DMAEMA) were prepared by a free radical polymerization at for 12 h. The weight ratio of NIPAM to DMAEMA monomer was 95/5. The copolymer was identified by -NMR. Releases from the alginate beads were observed at 30, 37, and using blue dextran or FITC-dextran(fluorescein isothiocyanate-dextran) as a model drug. The effect of temperature on the degree of release from the beads was insignificant. FITC-dextran was released more than blue dextran possibly due to its smaller molecular weight. |
| Starting Page | 79 |
| Ending Page | 83 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.7317/pk.2010.34.1.79 |
| Volume Number | 34 |
| Alternate Webpage(s) | https://www.cheric.org/PDF/PK/PK34/PK34-1-0079.pdf |
| Alternate Webpage(s) | https://doi.org/10.7317/pk.2010.34.1.79 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
