NDLI: The Origin of Bacterial Resistance to Proflavine 2 . Spontaneous Mutation to Proflavine Resistance in Escherichia coli BY

Content Provider	Semantic Scholar
Copyright Year	2008
Abstract	Experiments were performed to demonstrate the production in Eschem'chia coli of spontaneously occurring mutants resistant to proflavine. The fluctuation test of Luria & Delbriick (1943) suggested that such mutants arise. This was confirmed by a modification of the technique of Lederberg & Lederberg (1952). By this method of indirect selection by replica plating, two separate firststep mutants were isolated; from one of these was isolated a second-step mutant, and from this a third-step mutant. The resistance of the third-step mutant was about 100 times greater than that of the original sensitive strain. By the same technique, two first-step mutants to chloramphenicol resistance were isolated. None of the 6 mutants had come into contact with either drug until the time of testing. Crossresistance between proflavine and chloramphenicol was shown by 5 of the 6 mutants ; the sixth showed an increase in proflavine resistance though not in resistance to chloramphenicol.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.microbiologyresearch.org/docserver/fulltext/micro/20/2/mic-20-2-365.pdf?accname=guest&checksum=418F72F5D312DBB649464619535EC4E0&expires=1550782512&id=id
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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