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Palladium-catalyzed C(sp 3 )–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, K. X. Zhang, Shuo-Qing Shi, Bing-Feng |
| Copyright Year | 2016 |
| Abstract | A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral β-aryl-α-hydroxy acids. Further, the new reaction has also been applied to the synthesis of pharmaceutically important α-hydroxy acids, such as LY519818 and tesaglitazar. |
| Starting Page | 204 |
| Ending Page | 208 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C5QO00319A |
| Volume Number | 3 |
| Alternate Webpage(s) | http://authors.library.caltech.edu/64791/1/c5qo00319a.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C5QO00319A |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
