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Regulation of tissue factor-factor VIIa expression on cell surfaces: A role for tissue factor-factor VIIa endocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rao, L. Vijaya Mohan Pendurthi, Usha R. |
| Copyright Year | 2004 |
| Abstract | Tissue factor (TF) is the cellular receptor for plasma clotting factor VIIa (FVIIa) and the formation of TF-VIIa complexes on cell surfaces triggers the coagulation cascade. Further, TF-VIIa, either directly or indirectly, influences various biological processes, such as development, inflammation and tumor metastasis. Therefore, a proper regulation of TF-VIIa expression is critical for the maintenance of hemostatic balance and health in general. TF-VIIa functional expression on cell surfaces is regulated primarily by transcriptional regulation of TF gene or by specific plasma inhibitors, particularly tissue factor pathway inhibitor (TFPI). However, a number of other mechanisms that are yet to be well defined also regulate TF-VIIa functional expression. One such mechanism is the endocytosis of TF-VIIa. In this article, we provide a comprehensive review on the regulation of TF-VIIa functional expression by these other mechanisms, with a particular emphasis on TF-VIIa endocytosis, and our perspective of these studies. |
| Starting Page | 131 |
| Ending Page | 140 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1023/A:1026004208822 |
| PubMed reference number | 14619963 |
| Journal | Medline |
| Volume Number | 253 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1023/A:1026004208822 |
| Alternate Webpage(s) | https://doi.org/10.1023/A%3A1026004208822 |
| Journal | Molecular and Cellular Biochemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
