Loading...
Please wait, while we are loading the content...
Similar Documents
Dual effect of N-methyl-N-(1-methyl-4-pyrolidino)-2-butyl)acetamide on release of (3H)-acetylcholine prom the rat hippocampal slices
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sethy, Vimala H. Francis, Jonathan W. Russell, R. R. Ruppel, P. L. |
| Copyright Year | 1988 |
| Abstract | The effect of muscarinic cholinergic drugs on (3H)-acetylcholine [3H)-Ach) release from slices of rat hippocampus was investigated either in the presence of eserine or hemicholinium-3 (HC-3), 10 microM each. BM-5 (N-methyl-N-(1-methyl-4-pyrolidino-2-butyl)acetamide) is a partial muscarinic cholinergic agonist. Like oxotremorine, BM-5 significantly (p less than 0.012) decreased the release of (3H)-Ach in the presence of HC-3. In the presence of eserine, (3H)-Ach release was significantly (p less than 0.001) enhanced both by atropine and BM-5. The decrease or increase in release of (3H)-Ach by BM-5, in the presence of HC-3 or eserine, respectively, may be due to its partial agonist effect on hippocampal muscarinic cholinergic receptors. |
| Starting Page | 1191 |
| Ending Page | 1195 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0028-3908(88)90017-2 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0028390888900172 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0028390888900172?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 3205386 |
| Alternate Webpage(s) | https://doi.org/10.1016/0028-3908%2888%2990017-2 |
| Journal | Medline |
| Volume Number | 27 |
| Journal | Neuropharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
