NDLI: Hepatoprotective Activity of Ethanolic Extract of Eugenia Jambolana Leaf on Liver Damage Caused by Paracetamol in Rats

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Hepatoprotective Activity of Ethanolic Extract of Eugenia Jambolana Leaf on Liver Damage Caused by Paracetamol in Rats

Content Provider	Semantic Scholar
Author	Kumar, Yadalam Kiran Rao, Gattineni Srinivasa Santhiswaroop, M. Chandra, Subrato
Copyright Year	2016
Abstract	INTRODUCTION Medicinal plants are the oldest type of healthcare known, and have been used throughout history by many cultures. Many of the modern medicines are produced indirectly from medicinal plants, for example aspirin 1. Plants are directly used as medicines by a majority of cultures around the world, for example Chinese medicine and Indian ABSTRACT Ethanolic extract of Eugenia jambolana leaves were investigated for their Hepatoprotective potent ial against liver injury induced by paracetamol in rats. The li ver damage was induced in male albino rats (200 220gm) by administering paracetamol (2 gm/kg) for 7 days a nd extent of damage was studied by assessing the biochemical parameters such as Total bilirubin, Dir ect bilirubin, Indirect bilirubin, Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate t ransaminase (SGOT), Alkaline phosphatase (ALP), Total protein (TP), Albumin and Globulin. Histopath ological changes of liver sample were compared with respective control. Treatment of rats with ethanoli c extract (200mg/kg) for 7 days resulted in signifi cant hepatoprotection for total protein (6.6 g/dl) only, while at 400 mg/kg, the restoration was significan t for enzyme markers, viz. SGOT, SGPT, ALP (22.5 U/L, 18. 5 U/L, 58.5 U/L ) in paracetamol-treated rats. The lethal dose (LD50) of the plant was greater than 30 00 mg/kg. The ethanolic extracts of Eugenia jambolana leaves have protected liver from paracetamol damage agains t induced liver injury.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijrpns.com/article/HEPATOPROTECTIVE%20ACTIVITY%20OF%20ETHANOLIC%20EXTRACT%20OF%20EUGENIA%20JAMBOLANA%20LEAF%20ON%20LIVER%20DAMAGE%20CAUSED%20BY%20PARACETAMOL%20IN%20RATS.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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