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Diuretics as pathogenetic treatment for heart failure
| Content Provider | Semantic Scholar |
|---|---|
| Author | Guglin, Maya Guglin |
| Copyright Year | 2011 |
| Abstract | Increased intracardiac filling pressure or congestion causes symptoms and leads to hospital admissions in patients with heart failure, regardless of their systolic function. A history of hospital admission, in turn, predicts further hospitalizations and morbidity, and a higher number of hospitalizations determine higher mortality. Congestion is therefore the driving force of the natural history of heart failure. Congestion is the syndrome shared by heart failure with preserved and reduced systolic function. These two conditions have almost identical morbidity, mortality, and survival because the outcomes are driven by congestion. A small difference in favor of heart failure with preserved systolic function comes from decreased ejection fraction and left ventricular remodeling which is only present in heart failure with decreased systolic function. The magnitude of this difference reflects the contribution of decreased systolic function and ventricular remodeling to the progression of heart failure. The only treatment available for congestion is fluid removal via diuretics, ultrafiltration, or dialysis. It is the only treatment that works equally well for heart failure with reduced and preserved systolic function because it affects congestion, the main pathogenetic feature of the disease. Diuretics are pathogenetic therapy for heart failure. |
| Starting Page | 91 |
| Ending Page | 98 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 21403798v1 |
| DOI | 10.2147/ijgm.s16635 |
| Journal | International journal of general medicine |
| Volume Number | 4 |
| Alternate Webpage(s) | https://www.dovepress.com/getfile.php?fileID=8613 |
| Alternate Webpage(s) | https://pdfs.semanticscholar.org/d4e4/f5de3f3d8fbce77603c00e97de972ac47335.pdf |
| Alternate Webpage(s) | https://doi.org/10.2147/IJGM.S16635 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenergic beta-Antagonists Aldosterone Angiotensin-Converting Enzyme Inhibitors Angiotensins Artificial cardiac pacemaker Biologic Preservation Cardiac Resynchronization Therapy Cardio-Renal Syndrome Congestion Defibrillators Denominator Diastole Diuretics Echocardiography Ejection fraction (procedure) Heart Transplantation Heart failure Hospital admission Hospitalization Hypertensive disease Morbidity - disease rate Natural History Patients Premature ventricular contractions Pulmonary Hypertension Serotonin Antagonists Sudden Cardiac Death Tachycardia, Ventricular Ultrafiltration (procedure) Ventricular Fibrillation Ventricular Remodeling diastolic dysfunction left ventricular assist device |
| Content Type | Text |
| Resource Type | Article |
