NDLI: Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus

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Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus

Content Provider	Semantic Scholar
Author	Sukari, Mohd Aspollah Noor, Halimatul Saadiah Mohd Bakar, Nur Haslizawati Abu Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Rahmani, Mawardi Abdul, Ahmad Bustamam
Copyright Year	2013
Abstract	Phytochemical studies on different parts of Murraya koenigii (L.) have resulted in the isolation of six carbazole alkaloids which have been identified as mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4), murrayafoline-A (5) and 3-methylcarbazole (6) together with b-sitosterol. The structures of these compounds were established using spectroscopic techniques. The crude extracts and chemical constituents obtained from the isolation work were tested on its larvicidal activity against dengue fever mosquito, Aedes aegypti. Hexane extract from stem bark, roots and leaves of Murraya koenigii showed strong activity against Aedes aegypti followed by chloroform extract of the roots and leaves. Methanol extract of the leaves also showed strong activity while methanol extract of the roots showed moderate activity. Besides, chloroform and methanol extracts from stem bark showed strong activity. Similarly, pure compounds isolated from the plant, mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4) and murrayafoline A (5) exhibited strong activity against Aedes aegypti with LC50 values of less than 3 μg/mL.
File Format	PDF HTM / HTML
DOI	10.14233/ajchem.2013.14579
Volume Number	25
Alternate Webpage(s)	http://psasir.upm.edu.my/id/eprint/30151/1/Larvicidal%20carbazole%20alkaloids%20from%20Murraya%20koenigii%20against%20dengue%20fever%20mosquito%20Aedes%20aegypti%20Linnaeus.pdf
Alternate Webpage(s)	https://doi.org/10.14233/ajchem.2013.14579
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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