Ascorbic acid, metal ions and the superoxide radical.

Content Provider	Semantic Scholar
Author	Halliwell, Barry Foyer, Christine Helen
Copyright Year	1976
Abstract	1. No evidence could be found for production of the superoxide radical, O2-, during autoxidation of ascorbic acid at alkaline pH values. Indeed, ascorbate may be important in protection against O2- genat-d in vivo. 2. Oxidation of ascorbate at pH 10.2 was stimulated by metal ions. Stimulation by Fe2+ was abolished by superoxide dismutase, probably because of generation of O2-- during reduction of O2 by Fe2+, followed by reaction of O2-- with ascorbate. EDTA changed the mechanism of Fe2+-stimulated ascorbate oxidation. 3. Stimulation of ascorbate oxidation by Cu2+ was also decreased by superoxide dismutase, but this appears to be an artifact, since apoenzyme or bovine serum albumin showed similar effects.
Starting Page	697
Ending Page	700
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemj.org/content/ppbiochemj/155/3/697.full.pdf
PubMed reference number	182136v1
Volume Number	155
Issue Number	3
Journal	The Biochemical journal
Language	English
Access Restriction	Open
Subject Keyword	Apoenzymes Ascorbate Ascorbic Acid Cattle Edetic Acid Ferrous Ions L-Ascorbate oxidase Oxygen Serum Albumin Serum Albumin, Bovine Superoxide Dismutase Superoxides cupric cation oxidation
Content Type	Text
Resource Type	Article