Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation.

Content Provider	Semantic Scholar
Author	McKinney, Alexander M. Reichert, Patricia Short, James Dhurairaj, Thiruvenkatasamy Santacruz, Karen S. McKinney, Zach Kieffer, Stephen
Copyright Year	2006
Abstract	Giant cell tumor (GCT) of the sphenoid bone is a relatively rare entity and metachronous multicentric GCT of the sphenoid is even rarer; we are aware of only 3 previous cases in the literature. We describe here a tumor of the sphenoid bone that was identified 15 years after multiple resections of a GCT of the left inferior pubic ramus. Correlation is made between the histopathologic findings, MR imaging of the brain, CT of the head, and fusion positron-emission tomography (PET)/CT scan performed with fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG). This report is the first to describe the appearance of a GCT of the sphenoid bone on a fusion PET/CT examination. High metabolic activity in the base of the skull adjacent to the middle cranial fossa was demonstrated in a fashion similar to that of the known pelvic lesion. This case also demonstrates that the increased metabolic activity seen in a GCT of the sphenoid bone may be partially obscured by the adjacent physiologic high metabolic activity of the brain.
File Format	PDF HTM / HTML
PubMed reference number	17110693
Journal	Medline
Volume Number	27
Issue Number	10
Alternate Webpage(s)	http://www.ajnr.org/content/ajnr/27/10/2199.full.pdf
Journal	AJNR. American journal of neuroradiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article