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Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Choi, Ji Soo Yoon, Dahye Koo, Ja Seung Kim, Siwon Park, Vivian Youngjean Kim, Eun-Kyung Kim, Suhkmann Kim, Min Jung |
| Copyright Year | 2017 |
| Abstract | Estrogen receptor (ER)-positive breast cancers overall have a good prognosis, however, some patients suffer relapses and do not respond to endocrine therapy. The purpose of this study was to determine whether there are any correlations between high-resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) metabolic profiles of core needle biopsy (CNB) specimens and the molecular markers currently used in patients with ER-positive breast cancers. The metabolic profiling of CNB samples from 62 ER-positive cancers was performed by HR-MAS MRS. Metabolic profiles were compared according to human epidermal growth factor receptor 2 (HER2) and Ki-67 status, and luminal type, using the Mann-Whitney test. Multivariate analysis was performed with orthogonal projections to latent structure-discriminant analysis (OPLS-DA). In univariate analysis, the HER2-positive group was shown to have higher levels of glycine and glutamate, compared to the HER2-negative group (P<0.01, and P <0.01, respectively). The high Ki-67 group showed higher levels of glutamate than the low Ki-67 group without statistical significance. Luminal B cancers showed higher levels of glycine (P=0.01) than luminal A cancers. In multivariate analysis, the OPLS-DA models built with HR-MAS MR metabolic profiles showed visible discrimination between the subgroups according to HER2 and Ki-67 status, and luminal type. This study showed that the metabolic profiles of CNB samples assessed by HR-MAS MRS can be used to detect potential prognostic biomarkers as well as to understand the difference in metabolic mechanism among subtypes of ER-positive breast cancer. |
| Starting Page | 63405 |
| Ending Page | 63416 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=18822&path%5B%5D=60442 |
| PubMed reference number | 5609932 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.18822 |
| DOI | 10.18632/oncotarget.18822 |
| Journal | Oncotarget |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biological Markers Core needle biopsy Discriminant Analysis Estrogen Receptors Estrogens Glutamic Acid Glycine Growth Factor Receptors Hormone Therapy Ki67 Measurement Luminal Malignant Neoplasms Mammary Neoplasms Metabolic Process, Cellular Metabolic Profile Metabolomics P-Value Patients Projections and Predictions Specimen Subtype (attribute) estrogen receptor alpha, human heart rate |
| Content Type | Text |
| Resource Type | Article |
