NDLI: The GABAB receptor agonist baclofen prevents heroin-induced reinstatement of heroin-seeking behavior in rats

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The GABAB receptor agonist baclofen prevents heroin-induced reinstatement of heroin-seeking behavior in rats

Content Provider	Semantic Scholar
Author	Spano, Maria Sabrina Fattore, Liana Fratta, Walter Fadda, Paola
Copyright Year	2007
Abstract	Opiate addiction is a chronic relapsing disorder characterized by high rates of relapse. The gamma-aminobutyric acid GABA(B) receptor agonist baclofen is known to affect the reinforcing effects of several drugs of abuse, including heroin, as well as to decrease cue-maintained responding for heroin, cocaine and nicotine and suppress alcohol deprivation effect in rats. Here we studied the effect of baclofen on the reinstatement of extinguished heroin-seeking behavior triggered by a priming injection of heroin in abstinent rats trained to stably self-administer heroin (30 microg/kg per infusion) under a continuous reinforcement schedule. Following extinction, the effect of non-contingent non-reinforced primings with heroin, baclofen or heroin/baclofen combination on the resumption of responding was evaluated. Results indicate that heroin priming (0.25mg/kg) promptly reinitiated heroin-seeking behavior, an effect dose-dependently reduced by baclofen at doses (0.625 and 1.25mg/kg) not affecting responding per sè. Importantly, baclofen did not affect locomotion either alone or in combination with heroin, dispelling any doubt as to the eliciting of possible non-specific (motor) effects. The present results show that GABA(B) receptor activation may reduce the propensity to resume drug-induced heroin-seeking behavior thus offering a possible approach in maintaining opiate abstinence.
Starting Page	1555
Ending Page	1562
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/j.neuropharm.2007.02.012
PubMed reference number	17451755
Journal	Medline
Volume Number	52
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0028390807000597
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0028390807000597?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.neuropharm.2007.02.012
Journal	Neuropharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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