NDLI: Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells

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Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells

Content Provider	Semantic Scholar
Author	Lee, Kwan Young Jang, Yujin Lee, Min Hee Kim, Young Im Jung, Sung-Cherl Han, Seung-Yun Kim, Se Hoon Park, Hyung Seo Kim, Dong Kwan
Copyright Year	2018
Abstract	Objective Propofol is an intravenously administered anesthetic that enhances γ-aminobutyric acid-mediated inhibition in the central nerve system. Other mechanisms may also be involved in general anesthesia. Propofol has been implicated in movement disorders. The cerebellum is important for motor coordination and motor learning. The aim of the present study was to investigate the propofol effect on excitatory synaptic transmissions in cerebellar cortex. Methods Excitatory postsynaptic currents by parallel fiber stimulation and complex spikes by climbing fiber stimulation were monitored in Purkinje cells of Wister rat cerebellar slice using whole-cell patch-clamp techniques. Results Decay time, rise time and amplitude of excitatory postsynaptic currents at parallel fiber Purkinje cell synapses and area of complex spikes at climbing fiber Purkinje cell synapses were significantly increased by propofol administration. Conclusion The detected changes of glutamatergic synaptic transmission in cerebellar Purkinje cell, which determine cerebellar motor output, could explain cerebellar mechanism of motor deficits induced by propofol.
Starting Page	176
Ending Page	183
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	29739131v1
Alternate Webpage(s)	https://doi.org/10.9758/cpn.2018.16.2.176
DOI	10.9758/cpn.2018.16.2.176
Journal	Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
Volume Number	16
Language	English
Access Restriction	Open
Subject Keyword	Cellular Phone Cerebellar cortex structure Cerebellum Excitatory Postsynaptic Currents Motor Neuron Disease Movement Disorders Patch-Clamp Techniques Postsynaptic Current Propofol Synapses Synaptic Transmission Thioctic Acid Tissue fiber calcium polycarbophil 625 MG Oral Tablet parallel fiber
Content Type	Text
Resource Type	Article

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