NDLI: Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

Content Provider	Semantic Scholar
Author	Jacobson, Nils Szabo, Susanne J. Weber-Nordt, R. M. Zhong, Z. Schreiber, Robert D. Darnell, James E. Murphy, Kenneth M.
Copyright Year	1995
Abstract	Interleukin 12 (IL-12) initiates the differentiation of naive CD4+ T cells to T helper type 1 (Th1) cells critical for resistance to intracellular pathogens such as Leishmania major. To explore the basis of IL-12 action, we analyzed induction of nuclear factors in Th1 cells. IL-12 selectively induced nuclear DNA-binding complexes that contained Stat3 and Stat4, recently cloned members of the family of signal transducers and activators of transcription (STATs). While Stat3 participates in signaling for several other cytokines, Stat4 was not previously known to participate in the signaling pathway for any natural ligand. The selective activation of Stat4 provides a basis for unique actions of IL-12 on Th1 development. Thus, this study presents the first identification of the early events in IL-12 signaling in T cells and of ligand activation of Stat4.
Starting Page	1755
Ending Page	1762
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1084/jem.181.5.1755
PubMed reference number	7722452
Journal	Medline
Volume Number	181
Journal	The Journal of experimental medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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