[Acute respiratory distress syndrome: case series, two years at an intensive care unit].

Content Provider	Semantic Scholar
Author	Taborda, Lúcia Barros, Filipa Fonseca, Vitor Irimia, Manuel Carvalho, Ramiro Diogo, Cláudia Ramos, Armindo
Copyright Year	2014
Abstract	INTRODUCTION Acute Respiratory Distress Syndrome has a significant incidence and mortality at Intensive Care Units. Therefore, more studies are necessary in order to develop new effective therapeutic strategies. The authors have proposed themselves to characterize Acute Respiratory Distress Syndrome patients admitted to an Intensive Care Unit for 2 years. MATERIAL AND METHODS This was an observational retrospective study of the patients filling the Acute Respiratory Distress Syndrome criteria from the American-European Consensus Conference on ARDS, being excluded those non invasively ventilated. Demographic data, Acute Respiratory Distress Syndrome etiology, comorbidities, Gravity Indices, PaO2/FiO2, ventilator modalities and programmation, pulmonary compliance, days of invasive mechanical ventilation, corticosteroids use, rescue therapies, complications, days at Intensive Care Unit and obits were searched for and were submitted to statistic description and analysis. RESULTS A 40 patients sample was obtained, with a median age of 72.5 years (interquartile range = 22) and a female:male ratio of ≈1:1.86. Fifty five percent of the Acute Respiratory Distress Syndrome cases had pulmonary etiology. The mean minimal PaO2/FiO2 was 88 mmHg (CI 95%: 78.5-97.6). The mean maximal applied PEEP was 12.4 cmH2O (Standard Deviation 4.12) and the mean maximal used tidal volume was 8.2 mL/ Kg ideal body weight (CI 95%: 7.7-8.6). The median invasive mechanical ventilation days was 10. Forty seven and one half percent of the patients had been administered corticosteroids and 52.5% had been submitted to recruitment maneuvers. The most frequent complication was Ventilator Associated Pneumonia (20%). The median Intensive Care Unit stay was 10.7 days (interquartile range 10.85). The fatality rate was 60%. The probability of the favorable outcome 'non-death in Intensive Care Unit' was 4.4x superior for patients who were administered corticosteroids and 11x superior for patients < 65 years old. DISCUSSION AND CONCLUSIONS Acute Respiratory Distress Syndrome is associated with long hospitalization and significant mortality. New prospective studies will be necessary to endorse the potential benefit of steroid therapy and to identify the subgroups of patients that warrant its use.
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Alternate Webpage(s)	https://www.actamedicaportuguesa.com/revista/index.php/amp/article/download/4266/4117
PubMed reference number	24813489v1
Volume Number	27
Issue Number	2
Journal	Acta medica portuguesa
Language	English
Access Restriction	Open
Subject Keyword	Adrenal Cortex Hormones Centimeters of Water Cessation of life Exclusion Hospitalization Idiopathic Pulmonary Fibrosis Interquartile Range Mechanical ventilation Partial Pressure Arterial Oxygen to Fraction Inspired Oxygen Ratio Measurement Patients Pneumonia Pneumonia, Ventilator-Associated Respiration Respiratory Distress Syndrome Statistic (data) Steroid therapy Steroids Therapeutic procedure Ventilator - respiratory equipment intensive care unit torr
Content Type	Text
Resource Type	Article