NDLI: Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts.

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Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts.

Content Provider	Semantic Scholar
Author	Moon, Hee Jung Lee, Sang Ho Ku, Mi Jeong Yu, Byeng Chul Jeong, Seok Hoon Stonik, Valentin A. Zvyagintseva, Tatyana N. Ermakova, Svetlana P. Lee, Yong Hwan
Copyright Year	2009
Abstract	UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-1) levels in human skin and plays a major role in the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-1 expression at the protein and mRNA levels in human skin fibroblasts (HS68). Yet, the effects of fucoidan on UVB-induced MMP-1 promoter activity and type I procollagen have not been investigated. In this study, we assessed the effects of fucoidan on the inhibition of MMP-1 promoter activity and on the increase of type I procollagen synthesis in human skin fibroblasts. Fucoidan treatment significantly inhibited MMP-1 promoter activity compared to UVB irradiation alone. Fucoidan treatment also increased type I procollagen mRNA and protein expression in a dose-dependent manner compared to the control. Our data indicate that fucoidan may prevent UVB-induced MMP-1 expression and inhibit down-regulation of type I procollagen synthesis. We suggest that fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
File Format	PDF HTM / HTML
DOI	10.1684/ejd.2008.0611
PubMed reference number	19129083
Journal	Medline
Volume Number	19
Issue Number	2
Alternate Webpage(s)	http://www.laminarinase.narod.ru/09_19_129.pdf
Alternate Webpage(s)	https://doi.org/10.1684/ejd.2008.0611
Journal	European journal of dermatology : EJD
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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