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Acute electronic cigarette use: nicotine delivery and subjective effects in regular users
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dawkins, Lynne Corcoran, Olivia |
| Copyright Year | 2013 |
| Abstract | RationaleElectronic cigarettes are becoming increasingly popular among smokers worldwide. Commonly reported reasons for use include the following: to quit smoking, to avoid relapse, to reduce urge to smoke, or as a perceived lower-risk alternative to smoking. Few studies, however, have explored whether electronic cigarettes (e-cigarettes) deliver measurable levels of nicotine to the blood.ObjectiveThis study aims to explore in experienced users the effect of using an 18-mg/ml nicotine first-generation e-cigarette on blood nicotine, tobacco withdrawal symptoms, and urge to smoke.MethodsFourteen regular e-cigarette users (three females), who are abstinent from smoking and e-cigarette use for 12 h, each completed a 2.5 h testing session. Blood was sampled, and questionnaires were completed (tobacco-related withdrawal symptoms, urge to smoke, positive and negative subjective effects) at four stages: baseline, 10 puffs, 60 min of ad lib use and a 60-min rest period.ResultsComplete sets of blood were obtained from seven participants. Plasma nicotine concentration rose significantly from a mean of 0.74 ng/ml at baseline to 6.77 ng/ml 10 min after 10 puffs, reaching a mean maximum of 13.91 ng/ml by the end of the ad lib puffing period. Tobacco-related withdrawal symptoms and urge to smoke were significantly reduced; direct positive effects were strongly endorsed, and there was very low reporting of adverse effects.ConclusionsThese findings demonstrate reliable blood nicotine delivery after the acute use of this brand/model of e-cigarette in a sample of regular users. Future studies might usefully quantify nicotine delivery in relation to inhalation technique and the relationship with successful smoking cessation/harm reduction. |
| Starting Page | 401 |
| Ending Page | 407 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00213-013-3249-8 |
| PubMed reference number | 23978909 |
| Journal | Medline |
| Volume Number | 231 |
| Alternate Webpage(s) | http://roar.uel.ac.uk/3543/1/Dawkins%20and%20Corcoran_ecig_accepted%20version.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s00213-013-3249-8 |
| Journal | Psychopharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
