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Genomic Profiling of Thyroid Nodules: Current Role for ThyroSeq Next-Generation Sequencing on Clinical Decision-Making
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kargi, Atil Y. Bustamante, Marcela Perez Gulec, Seza |
| Copyright Year | 2016 |
| Abstract | In recent years there has been an increased awareness of the genetic alterations underlying both benign and malignant neoplasms of the thyroid. Next-generation sequencing (NGS) is an emerging technology that allows for rapid detection of a large number of genetic mutations in thyroid fine-needle aspiration (FNA) specimens. NGS for targeted mutational analysis in thyroid tumors has been proposed as a tool to assist in the diagnosis of thyroid nodules with indeterminate FNA cytology. Results of genomic testing of thyroid nodules and thyroid cancers could also have prognostic implications and play a role in determining optimal treatment strategies including targeted therapies. We provide a critical review of existing studies assessing the performance of the ThyroSeq NGS test for the diagnosis and management of patients with thyroid nodules with indeterminate cytopathology and discuss the applicability of findings from these studies to clinical practice. While there are early indications to suggest a possible utility of data obtained from NGS to aid in prognostication and therapeutic decision-making in thyroid cancer, we recommend judicious use and cautious interpretation of such molecular testing until results of ongoing clinical trials become available. Lastly, we discuss recommendations provided from clinical practice guidelines regarding the use of mutation detection via NGS in the diagnostic evaluation of thyroid nodules. |
| Starting Page | 24 |
| Ending Page | 35 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://digitalcommons.fiu.edu/cgi/viewcontent.cgi?article=1113&context=com_facpub |
| Alternate Webpage(s) | https://digitalcommons.fiu.edu/cgi/viewcontent.cgi?article=1113&context=com_facpub&httpsredir=1&referer= |
| PubMed reference number | 28117287v1 |
| Alternate Webpage(s) | https://doi.org/10.4274/2017.26.suppl.04 |
| DOI | 10.4274/2017.26.suppl.04 |
| Journal | Molecular imaging and radionuclide therapy |
| Volume Number | 26 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Achyrocline Anaplastic thyroid carcinoma Biopolymer Sequencing Cervical Atlas Decision Making Fine needle aspiration biopsy Fine-needle biopsy Malignant Neoplasms Mutation Neoplastic disease Nucleopolyhedrovirus Numerous Patients Practice Guidelines as Topic Precision Medicine Specimen Therapeutic procedure Thyroid Diseases Thyroid Neoplasm Thyroid Nodule science of Cytology and Pathology |
| Content Type | Text |
| Resource Type | Article |
