Analysis of the ontogeny of galanin in the rat central nervous system by immunohistochemistry and radioimmunoassay

Content Provider	Semantic Scholar
Author	Sizer, Andrew Ro̊kaeus, Å. Foster, George A.
Copyright Year	1990
Abstract	The development of galanin-like immunoreactivity in the rat central nervous system has been investigated immunologically. Galanin-positive processes in the central nervous system were first recognized at day 1 post-natal, in the dorsal horn of the spinal cord. At day 2, the first galanin-immunoreactive neuronal somata were visualized in several regions of the diencephalon; at later stages of maturation positive cells were also detected in many brain stem areas. The number, density and staining intensity of galanin-positive structures in these and other regions increased steadily until day 28, by which age the adult disposition was attained. Increases in the concentrations of galanin-like immunoreactivity during maturation of the animals closely paralleled the immunohistochemical findings. No reduction in galanin-like immunoreactivity was noted in any area during later post-natal ages. The present study indicates that the ontogeny of galanin-like immunoreactivity in the rat central nervous system occurs entirely post-natally. The developmental profile is consistent with the role of galanin as a putative neurotransmitter/neuromodulator in the rat brain and spinal cord.
Starting Page	81
Ending Page	97
Page Count	17
File Format	PDF HTM / HTML
DOI	10.1016/0736-5748(90)90025-W
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/073657489090025W
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/073657489090025W?dgcid=api_sd_search-api-endpoint
PubMed reference number	1688680
Alternate Webpage(s)	https://doi.org/10.1016/0736-5748%2890%2990025-W
Journal	Medline
Volume Number	8
Journal	International Journal of Developmental Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article