NDLI: Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature.

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Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature.

Content Provider	Semantic Scholar
Author	Pantano, Flaminia Mannocchi, Giulio Marinelli, Enrico Gentili, Sebastián Graziano, Silvia Busardò, Francesco Paolo Luca, Natale Mario Di
Copyright Year	2017
Abstract	The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper. Identification of significant scientific literature was performed via the following research databases: Cochrane Central, Google Scholar, EMBASE, Medline, Science Direct, Scopus, Web of Science, using the following keywords: "Chelidonium majus", "greater celandine", "Hepatotoxicity", "Liver" "Injury", "Toxicity" individually investigated and then again in association. CM named also greater celandine, swallow-wort, or bai-qu-cai (Chinese), has been used for a long time in traditional Chinese medicine and phytotherapy. Its extracts have been claimed to display a wide variety of biological activities: antimicrobial, anti-inflammatory, spasmolytic, antineoplastic, hepatoprotective, and analgesic. Moreover, herbal medicine suggests this plant have numerous additional effects which have not yet been scientifically evaluated, such as antitussive, diuretic, and eye-regenerative. However, despite its claimed hepatoprotective effects, several hepatotoxicity cases have been reported to be probably or highly probably connected with CM exposure, after their evaluation through liver-targeted causality assessment methods. CM hepatotoxicity has been defined as a distinct form of herb-induced liver injury (HILI), due to an idiosyncratic reaction of the metabolic type. This evidence has to be considered in relationship with the absence of considerable benefits of CM therapy. Therefore, the risk to benefit ratio of the use of herbal products containing greater celandine can actually be considered as negative.
Starting Page	46
Ending Page	52
Page Count	7
File Format	PDF HTM / HTML
PubMed reference number	28379595
Journal	Medline
Volume Number	21
Issue Number	1
Alternate Webpage(s)	http://www.europeanreview.org/wp/wp-content/uploads/46-52-Hepatotoxicity-induced-by-greater-celandine-Chelidonium-majus-L.-a-review-of-the-literature.pdf
Journal	European review for medical and pharmacological sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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