Prenatal exposure to low concentrations of carbon monoxide alters habituation and non-spatial working memory in rat offspring

Content Provider	Semantic Scholar
Author	Giustino, Arcangela Cagiano, Raffaele Carratu', Maria Rosaria Cassano, Tommaso Cuomo, Vincenzo
Copyright Year	1999
Abstract	Inhalation of low concentrations (75 and 150 ppm) of carbon monoxide (CO) by pregnant rats from days 0 to 20 of gestation leads to alterations in habituation and working memory in young adult male offspring subjected to the novel exploration object test. In particular, lack of habituation upon the second presentation of the objects and failure in the ability to discriminate between the novel and the familiar object were found in CO (75 and 150 ppm)-exposed offspring. These alterations were not accompanied by changes in spontaneous motor activity (open field test). The subtle behavioral deficits observed in the present study have been produced by prenatal exposure to CO levels resulting in maternal blood carboxyhaemoglobin (HbCO) concentrations equivalent to those observed in human cigarette smokers.
Starting Page	201
Ending Page	205
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(99)01832-6
PubMed reference number	10536278
Journal	Medline
Volume Number	844
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899399018326
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899399018326?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2899%2901832-6
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article