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Catalytic Synthesis of Novel N-( 2 H-chromen-3-yl )-phenylacetamide Derivatives and their Antibacterial Activity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hoti, Ramiz Paçarizi, Musaj Ibrahimi, Izet Sadiku, Makfire Troni, Naser Ismaili, Hamit Thaçi, Veprim Selimaj, Vesa Haxhiu, Fidane |
| Copyright Year | 2017 |
| Abstract | In this study is reported about a series of substituted phenylacetamide derivatives with coumarin moiety. Novel N-(2H-chromen-3yl)-phenylacetamide derivatives 4(a-f) were synthesized by one pot catalytic reaction of 4-hydroxycoumarin 1, benzaldehyde analogues 2(a-f) and acetamide. Reactions are performed under reflux conditions using nano-Feo and nano-ZnO as surface catalysts. The structures of the synthesised compounds were established by FT-IR and NMR spectrometric data and their elemental analysis. Compounds of series 4(a-f) were screened for their antibacterial activity against S. aureus, E. coli and Klebsiella by Diffusion Disc Method. Antibacterial activity of the synthesized compounds was examined by measuring the zones of inhibition around the disks impregnated with the corresponding solutions in N, N-DMF concentration 2 mg/mL , 4 mg/mL and 6 mg/mL. The synthesized compounds exhibited considerable antibacterial activity. Also the impact of substitutions in antimicrobial activity is explored. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://globalresearchonline.net/journalcontents/v47-2/07.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
