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Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sulik, Michael J. Eisenberg, Nancy Spinrad, Tracy L. Lemery-Chalfant, Kathryn Stover, Daryn A. Verrelli, Brian C. |
| Copyright Year | 2016 |
| Abstract | Children's observed effortful control (EC) at 30, 42, and 54 months (n = 145) was predicted from the interaction between mothers' observed parenting with their 30-month-olds and three variants of the solute carrier family C6, member 3 (SLC6A3) dopamine transporter gene (single nucleotide polymorphisms in intron8 and intron13, and a 40 base pair variable number tandem repeat [VNTR] in the 3'-untranslated region [UTR]), as well as haplotypes of these variants. Significant moderating effects were found. Children without the intron8-A/intron13-G, intron8-A/3'-UTR VNTR-10, or intron13-G/3'-UTR VNTR-10 haplotypes (i.e., haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning) appeared to demonstrate altered levels of EC as a function of maternal parenting quality, whereas children with these haplotypes demonstrated a similar EC level regardless of the parenting quality. Children with these haplotypes demonstrated a trade-off, such that they showed higher EC, relative to their counterparts without these haplotypes, when exposed to less supportive maternal parenting. The findings revealed a diathesis-stress pattern and suggested that different SLC6A3 haplotypes, but not single variants, might represent different levels of young children's sensitivity/responsivity to early parenting. |
| Starting Page | 199 |
| Ending Page | 212 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.1017/S0954579415000383 |
| PubMed reference number | 25924976 |
| Journal | Medline |
| Volume Number | 28 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://steinhardt.nyu.edu/scmsAdmin/media/users/aa1744/Yi_Sulik_Eisenberg_Spinrad_Lemery-Chalfant_Stover__Verrelli_2015.pdf |
| Alternate Webpage(s) | https://doi.org/10.1017/S0954579415000383 |
| Journal | Development and psychopathology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
