NDLI: Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway.

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Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway.

Content Provider	Semantic Scholar
Author	Yuan, Li-Lian Adams, Joseph P. Swank, Michael W. Sweatt, J. David Johnston, Daniel
Copyright Year	2002
Abstract	We investigated mitogen-activated protein kinase (MAPK) modulation of dendritic, A-type K+ channels in CA1 pyramidal neurons in the hippocampus. Activation of cAMP-dependent protein kinase A (PKA) and protein kinase C (PKC) leads to an increase in the amplitude of backpropagating action potentials in distal dendrites through downregulation of transient K+ channels in CA1 pyramidal neurons in the hippocampus. We show here that both of these signaling pathways converge on extracellular-regulated kinases (ERK)-specific MAPK in mediating this reduction in dendritic K+ current, which is confirmed, in parallel, by biochemical assays using phosphospecific antibodies against the ppERK and pKv4.2. Furthermore, immunostaining indicates dendritic localization of ppERK and pKv4.2. Taken together, these results demonstrate that dendritic, A-type K+ channels are dually regulated by PKA and PKC through a common downstream pathway involving MAPK, and the modulation of these K+ channels may be accounted for by the phosphorylation of Kv4.2 subunits.
Starting Page	319
Ending Page	328
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://clm.utexas.edu/djlab/pdfs/Yuan-Paige-2002.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/22/12/4860.full.pdf
Alternate Webpage(s)	http://clm.utexas.edu/djlab/pdfs/Yuan-Paige-2002.pdf
Alternate Webpage(s)	http://utw10020.utweb.utexas.edu/djlab/pdfs/Yuan-Paige-2002.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/22/12/4860.full.pdf
PubMed reference number	12077183v1
Volume Number	22
Issue Number	12
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	8-chloro-cyclic adenosine monophosphate Action Potentials CA1 field Convergence (action) Cyclic AMP-Dependent Protein Kinases Dendrites Down-Regulation Mitogen-Activated Protein Kinases Mitogens Potassium Protein Kinase C Pyramidal Cells
Content Type	Text
Resource Type	Article

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