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Synthesis and pharmacological investigations of azetidinone derivatives involving naphtho(2,1-b)furan-2-carboxamide
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mn, Kumaraswamy Vp, Vaidya Chandrasekhar, Cheemalamarri Mathias, Prathima |
| Copyright Year | 2013 |
| Abstract | The reaction of naphtho[2,1-b]furan-2-carbohydrazide 2, which in turn was synthesized from ethyl naphtho[2,1-b]furan-2carboxylate 1, with various aromatic aldehydes in refluxing dioxane afforded N[(aryl)methylene]naphtho[2,1-b] furan-2-carbohydrazides 3a-f. These hydrazones 3a-f on treatment with chloroacetyl chloride in presence of triethylamine produced, title compounds, azetidinone derivatives 4a-f. The structures of the newly synthesized compounds have been established by analytical and spectral studies and investigated for antibacterial, antifungal, anti-inflammatory, diuretic, anthelmintic and antipyretic activities. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.rjpbcs.com/pdf/2013_4(1)/%5B10%5D.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |