NDLI: Cuál es su diagnóstico

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Cuál es su diagnóstico

Content Provider	Semantic Scholar
Author	Burgos, Rocío Sánchez Cuéllar, Ignacio Navarro Vera, José Luis Del Castillo Pardo De Soto, María José Morán García, Miguel Burgueño
Copyright Year	2010
Abstract	La hidroxiurea (HU) es una droga antitumoral utilizada principalmente en enfermedades hematologicas. Es generalmente bien tolerada; sin embargo, puede asociarse a efectos adversos mucocutaneos severos, como ulceras acrales. La patogenia de estas ulceras es desconocida, y su aparicion se relaciona a la patologia de base, tiempo y dosis administrada. Son muy dolorosas, frecuentemente multiples y por lo general revierten en forma espontanea al suspender el medicamento. La region maleolar es la mas comunmente comprometida. Presentamos el caso de una paciente de sexo femenino, de 64 anos, en tratamiento con HU por policitemia vera, que presento ulceras acrales a los tres anos de tratamiento, con excelente evolucion tras la suspension del farmaco. Es fundamental conocer la existencia de estos efectos adversos para sospecharlos precozmente y realizar un oportuno diagnostico y tratamiento. Hydroxyurea (HU) is an antitumor drug commonly used in haematological diseases. It is usually well tolerated, however, it may be associated with severe muco-cutaneous side effects such as acral ulcers. The pathogenesis of these ulcers is unknown, and their appearance is related to the main disease, time and dosage. They are very painful, often multiple, an spontenous resolution after drug suspension is observed. The malleolus region is the most common site affected. We present the case of a 64-year-old woman with polycythemia vera treated with HU who developed acral ulcers after 3 years of treatment, with excellent response after drug discontinuation. For an opportune diagnosis and treatment of these side effects, it is very important to know of their existence and suspect that they may appear in advance.
Starting Page	128
Ending Page	129
Page Count	2
File Format	PDF HTM / HTML
DOI	10.1016/j.maxilo.2011.07.011
Volume Number	33
Alternate Webpage(s)	http://svderma.org/revista/index.php/ojs/article/download/232/232
Alternate Webpage(s)	http://revista.svderma.org/index.php/ojs/article/download/216/216
Alternate Webpage(s)	https://doi.org/10.1016/j.maxilo.2011.07.011
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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