NDLI: Molecular diversity from the three-component reaction of 2-hydroxy-1,4-naphthaquinone, aldehydes and 6-aminouracils: a reaction condition dependent MCR

Content Provider	Semantic Scholar
Author	Bharti, Ruchi Kumari, Pooja Parvin, Tasneem Choudhury, Lokman H.
Copyright Year	2017
Abstract	The three-component reaction of 2-hydroxy-1,4-naphthaquinone, aldehydes, and 6-aminouracil derivatives in acetic acid/water (1 : 1; v/v) under microwave heating conditions provides 1,4-dihydropyridines fused with naphthaquinone and pyrimidines. On the other hand the same reaction combinations under conventional reflux conditions provide acyclic trisubstituted methane derivatives. Using these tuneable reaction conditions a series of polycyclic fused N-heterocycles has been synthesized. The notable features of this methodology are a simple metal-free one-pot operation, easy purification process, use of the green solvent water, short reaction time and good to moderate yields of the products.
Starting Page	3928
Ending Page	3933
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1039/C6RA18828A
Volume Number	7
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2017/ra/c6ra18828a
Alternate Webpage(s)	http://www.rsc.org/suppdata/c6/ra/c6ra18828a/c6ra18828a1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C6RA18828A
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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