NDLI: Neocortical synchronized oscillations induced by thalamic disinhibition in vivo.

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Neocortical synchronized oscillations induced by thalamic disinhibition in vivo.

Content Provider	Semantic Scholar
Author	Castro-Alamancos, Manuel A.
Copyright Year	1999
Abstract	Thalamocortical circuits are recognized as the main elements involved in the genesis of synchronized oscillations typical of certain generalized seizures. We addressed the capability of thalamic disinhibition to generate synchronized oscillations in neocortex. Microdialysis was used to infuse GABA(A) and GABA(B) receptor antagonists directly into the thalamus of anesthetized rats while recording cortical field potentials from 16 sites aligned perpendicular to the cortical surface, using 100 microm spaced linear array silicon probes. The results demonstrate that block of thalamic GABA(A) receptors induces continuous 3 Hz discharges in neocortex and that thalamic GABA(B) receptors mediate this activity. Also, during thalamic disinhibition sporadic long-lasting discharges at 12 Hz occur that do not depend on GABA(B) receptors. Current source density analysis of these activities revealed that the dynamics of sinks and sources for the 3 and 12 Hz discharges was quite distinct, in a way that suggests a different active involvement of the neocortex. The results indicate that intrathalamic inhibitory processes play an essential role in the generation of neocortical synchronized oscillatory activity that may be related to certain forms of generalized seizures.
Starting Page	RC27
Ending Page	RC27
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/19/18/RC27.full.pdf
PubMed reference number	10479720v1
Volume Number	19
Issue Number	18
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Alignment Blood product source:Type:Pt:^BPU:Nom Body Fluid Discharge Hertz (Hz) Microdialysis Neocortex Seizures Silicon Social disinhibition Thalamic structure gamma-Aminobutyric Acid
Content Type	Text
Resource Type	Article

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