NDLI: Comparison of high sensitive C-reactive protein levels with other biomarkers in cardiovascular disease risk assessment

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Comparison of high sensitive C-reactive protein levels with other biomarkers in cardiovascular disease risk assessment

Content Provider	Semantic Scholar
Author	Gecgel, Sanem Karadag Huysal, Kağan
Copyright Year	2019
Abstract	This study aimed to investigate the correlation of high sensitive C-reactive protein (hs-CRP) levels with other biomarkers which were used for cardiovascular disease (CVD) risk determination. The hs-CRP levels measured by immunonephelometry (Behring Nephelometer II, U.S.A.). Complete blood count parameters and biochemical parameters were determined by a fully automated hematology analyzer and automatic biochemical analyzer (Becman Coulter, U.S.A.). The hs-CRP levels were mostly correlated with erythrocyte sedimentation rate (ESR) and albumin levels. Significantly low hemoglobin (HGB) and hematocrit (HCT) levels were determined in patients with high CVD risk according to hs-CRP levels. High-neutrophil and low-lymphocyte levels were found to be more effective than total white blood cell (WBC) levels for CVD risk. Red cell distribution width (RDW) levels were found significantly higher in the high hs-CRP CVD risk group than in the low hs-CRP CVD risk group in only male patients. There was no significant association between low-density lipoprotein (LDL), high-density lipoprotein (HDL) and hs-CRP CVD risk values. In conclusion, according to our study, the hs-CRP was an effective biomarker that could be used to assess CVD risk with other conventional biomarkers. Hematologic and inflammatory parameters as ESR, albumin, HGB, HCT, neutrophil, lymphocyte and RDW should be accepted as indicative for CVD risk assessment in patients identified as high CVD risk group according to the hs-CRP test. Although LDL and HDL were accepted as classical biomarkers to evaluate CVD risk, new laboratory test parameters independent of LDL and HDL have to be taken into consideration for CVD risk determination.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijcem.com/files/ijcem0079063.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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