Simultaneous Electrochemical Determination of Uric Acid and Ascorbic Acid Using L -Cysteine Self-Assembled Gold Electrode

Content Provider	Semantic Scholar
Author	Zhao, Yuqing Bai, Junyue Wang, Liang XuHong, E. Huang, Pengfei Wang, Hongjing
Copyright Year	2006
Abstract	The electrochemical behaviors of uric acid (UA) and ascorbic acid (AA) at the L-cysteine (L-Cys) selfassembled monolayers modified gold electrode (L-Cys/Au electrode) have been studied. The modified electrode shows an excellent electrocatalytical effect on the oxidation of UA and AA by cyclic voltammetry (CV) in 0.1 M phosphate buffer solution (pH 7.0). In differential pulse voltammetric (DPV) measurements, the L-Cys/Au electrode can separate the oxidation peak potentials of UA and AA present in homogeneous solution by about 236 mV though the bare electrode give a single broad response. A successful elimination of the fouling effect by the oxidized product of AA on the response of UA has been achieved at the L-Cys/Au electrode. The detection limit of UA and AA is 2.0 × 10 M and 1.1 × 10 M, respectively. The proposed method can be used for the determination of UA in urine sample. The method is simple, quick, sensitive and accurate.
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Language	English
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Content Type	Text
Resource Type	Article