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Activity-dependent conduction block in multifocal motor neuropathy: magnetic fatigue test.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nodera, Hiroyuki Bostock, Hugh Izumi, Yishin Nakamura, Kazuyuki Urushihara, Ryo Sakamoto, Taiko Murase, Nagako Shimazu, Hideki Kusunoki, Susumu Kaji, Ryuji |
| Copyright Year | 2006 |
| Abstract | BACKGROUND Multifocal motor neuropathy (MMN) is often misdiagnosed as motor neuron disease, especially when overt evidence of conduction block (CB) is lacking. Activity-dependent CB (ADCB), defined as transient CB induced by brief exercise, has been recently found in MMN but not in ALS. METHODS To test the diagnostic utility of ADCB for differentiating MMN from ALS, the authors recorded the compound muscle action potentials (CMAPs) from small hand muscles by magnetically stimulating nerve roots before and after 1 minute of maximal voluntary contraction (magnetic fatigue test). They examined nine patients with MMN with unequivocal clinical responses to IV immunoglobulins (IVIgs), yet lacked CB according to the conventional criteria. RESULTS Six MMN patients had postexercise CB/temporal dispersion maximum in the immediate postexercise period. ADCB in an MMN patient improved after IVIg. Further analysis revealed that prolongation of the duration from the onset to the positive peak of the CMAP was the most sensitive indicator for MMN, presumably because the phase cancellation obscures the abnormalities of the other parameters. CONCLUSION The magnetic fatigue test is useful in detecting mild conduction block presumably located in a proximal nerve segment in patients with multifocal motor neuropathy who do not fulfill its conventional electrodiagnostic criteria. |
| Starting Page | 162 |
| Ending Page | 168 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/brain/123/8/10.1093/brain/123.8.1602/2/1231602.pdf?Expires=1492487601&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Wgu8ybOZUsm8FB9iCHglnqKivhd60C72vplUPQCvu3l9r47mcyz0FMpJar389SPPlj8Cw0xZZM5x~PTZzFa5lGPPzv8IxYr0fh~p6EYLCHN3AYDkleFJAVSVDdxMizY4Mmf24cIJoCFYb5fRTgrBKg8yNQaoz2Xi8QDLVVS8GQ8AE59cwaBr3Wm9r4Nj2x7xInA6aVFuFkHu0a3rEz87VlBKpLu3U2LyIk1mO~Zt3XezXuC3Bsqx5zhmyl8Pc7Llbq2wQJwt-f5xS8zVV0Je5SKADTEm-4-piGDiOgteb3mGdzRZyn7NRWzJ5v4N~PHasd2eIA9XU8IOsXxwctGmtA__ |
| PubMed reference number | 16864821v1 |
| Volume Number | 67 |
| Issue Number | 2 |
| Journal | Neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Action Potentials Congenital Abnormality Fatigue Immunoglobulins Immunoglobulins, Intravenous Motor Neuron Disease Motor Neurons Multifocal motor neuropathy Myalgia Nerve root Patients Peripheral Neuropathy Peripheral motor neuropathy Stimulation (motivation) Tooth root structure nervous system disorder |
| Content Type | Text |
| Resource Type | Article |
