NDLI: Unrelated or mismatched related donor stem cell transplantation for myeloid malignancies with a fludarabine- and busulfan-based reduced-intensity conditioning regimen

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Unrelated or mismatched related donor stem cell transplantation for myeloid malignancies with a fludarabine- and busulfan-based reduced-intensity conditioning regimen

Content Provider	Semantic Scholar
Author	Ise, Mikiko Nakaseko, Chiaki Abe, Daijiro Oda, Kayo Ohwada, Chikako Ozawa, Shinichi Takeuchi, Masahiro Sakaida, Emiko Shimizu, N. Masuda, Shinichi Cho, Ryuko Nishimura, Miki Saito, Yasushi
Copyright Year	2008
Abstract	Many patients with myeloid malignancies are ineligible for conventional allogeneic hematopoietic stem cell transplantation (allo-HSCT) with myeloablative conditioning because of their age, medical problems, or the lack of a suitable HLA-identical related donor. The outcome of 9 patients with myeloid malignancies who underwent allo-HSCT following fludarabineand busulfanbased reduced intensity conditioning (RIC) from unrelated or mismatched related donor is herein described. Six patients received bone marrow from an unrelated donor, two received a serologically mismatched related allograft, and one received serologically mismatched unrelated cord blood. All patients demonstrated successfully engraftment at a median of 15 days and showed complete donor chimerism of 95% on day 28. One patient developed grade 3 regimen-related toxicity. Grade II to IV acute graft-versus-host disease (GVHD) and extensive type chronic GVHD developed in 6 and 4 patients, respectively. Of the two patients who received the second HSCT, one died of relapse and one died of acute GVHD. The remaining 7 patients are currently alive in remission. The overall survival at 4 years after allo-HSCT was 77.8%. These observations suggest that these RIC regimens enable rapid engraftment of stem cells from alternative donors with tolerable toxicities in patients who are not eligible for conventional HSCT.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://core.ac.uk/download/pdf/96972348.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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