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Synthesis and antiviral activity of novel spirocyclic nucleosides
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cobb, Alexander J. A. Isola, Antonio Dell’ Abdulsattar, Ban O. McLachlan, Matthew M. W. Neuman, Benjamin W. Müller, Christin R. Shankland, Kenneth Al-Mulla, Hawaa M. N. Binks, Alexander W. D. Elvidge, Warren |
| Copyright Year | 2018 |
| Abstract | The synthesis of a number of spirocyclic ribonucleosides containing either a triazolic or azetidinic system is described, along with two analogous phosphonate derivatives of the former. These systems were constructed from the same β-D-psicofuranose starting material. The triazole spirocyclic nucleosides were constructed using the 1-azido-1-hydroxymethyl derived sugars, where the primary alcohol was alkylated with a range of propargyl bromides, whereas the azetidine systems orginated from the corresponding 1-cyano-1-hydroxymethyl sugars. Owing to their close similarity with ribavirin, the library of compounds were investigated for their antiviral properties using MHV (Murine Hepatitis Virus) as a model. |
| Starting Page | 18363 |
| Ending Page | 18380 |
| Page Count | 18 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8nj02777c |
| Volume Number | 42 |
| Alternate Webpage(s) | http://centaur.reading.ac.uk/80622/1/FULL%20PAPER%20Spirocyclic%20post%20review%20v4.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c8nj02777c |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |