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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Namba, Yoshio Tomonaga, Masanori Kawasaki, Hiroshi Otomo, Eiichi Ikeda, Kazuhiko |
| Copyright Year | 1991 |
| Abstract | During the course of our immunohistochemical studies on the change of lipids in Alzheimer's disease brains by using antibody to apolipoprotein E, a protein having a special relevance to nervous tissue, we unexpectedly found that apo E immunoreactivity was associated with amyloid in both senile plaques and cerebral vessels and neurofibrillary tangles. The immunoreactivity was also found in amyloid of kuru plaques in Creutzfeldt-Jakob disease. Pretreatment of the sections with formic acid greatly enhanced immunoreactivity of senile and kuru plaques to antibody to apo E. |
| Starting Page | 163 |
| Ending Page | 166 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(91)91092-F |
| PubMed reference number | 2029618 |
| Journal | Medline |
| Volume Number | 541 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/000689939191092F |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/000689939191092F?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2891%2991092-F |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
