NDLI: Cortisol and ACTH release in dairy cows in response to machine milking after pretreatment with morphine and naloxone.

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Cortisol and ACTH release in dairy cows in response to machine milking after pretreatment with morphine and naloxone.

Content Provider	Semantic Scholar
Author	Tančin, Vladimír Schams, Dieter Kraetzl, W. D.
Copyright Year	2000
Abstract	The aim ot the study was to examine the effect of morphine and naloxone pretreatment on cortisol and ACTH concentrations in response to machine milking in dairy cows. In the first part of the experiment, the effects of i.v. morphine doses (0, 21, 70 and 210 mg, one dose each day) 10 min before morning milking were studied in six Brown Swiss dairy cows. In the second part, four cows were treated 1 d after the control milking with 210 mg morphine at 10 mm before milking and the next day with 210 mg naloxone at 15 min before milking followed by 210 mg morphine at 10 min before milking. In addition, four other cows were treated 1 d after the control milking with 210 mg naloxone at 10 min before milking. Pretreatment with morphine significantly suppressed the machine milking-induced increase of cortisol in blood plasma as compared with controls. Naloxone pretreatment overcame the inhibitory effect of morphine and elevated milking-induced cortisol concentrations. Naloxone administration alone significantly increased cortisol concentration resulting from milking as compared with controls. However, ACTH concentrations did not change in either control or treated animals, suggesting an ACTH-independent release mechanism for cortisol during milking. We conclude that the release of cortisol in response to machine milking seems to be modulated by emidogenous opioids at the adrenal level and does not appear to be under the control of ACTH.
File Format	PDF HTM / HTML
DOI	10.1017/S0022029900004374
PubMed reference number	11131061
Journal	Medline
Volume Number	67
Issue Number	4
Alternate Webpage(s)	https://mediatum.ub.tum.de/doc/1315575/1315575.pdf
Alternate Webpage(s)	https://doi.org/10.1017/S0022029900004374
Journal	The Journal of dairy research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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