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Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: A genetic approach using knockout mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vasconcelos, Anne Pereira De Riban, Véronique Wasterlain, Claude Guy Nehlig, Astrid |
| Copyright Year | 2006 |
| Abstract | The role of endothelial nitric oxide (NO) in the cerebrovascular response to partial seizures was investigated in mice deleted for the endothelial NO synthase gene (eNOS-/-) and in their paired wild-type (WT) congeners. Local cerebral blood flow (LCBF, quantitative [14C]iodoantipyrine method) was measured 3-6 h after unilateral kainate (KA) injection in the dorsal hippocampus; controls received saline. In WT mice, KA seizures induced a 22 to 50% LCBF increase restricted to the ipsilateral hippocampus, while significant LCBF decreases (15-33%) were noticed in 22% of the contralateral areas, i.e., the parietal cortex, amygdala and three basal ganglia areas, compared to saline-injected WT mice. In eNOS-/- mice, no LCBF increases were recorded within the epileptic focus and generalized contralateral LCBF decreases (22-46%) were noticed in 2/3 of the brain areas, compared to saline-injected eNOS-/- mice. Thus, endothelial NO is the mediator of the cerebrovascular response within the epileptic focus and participates in the maintenance of LCBF in distant areas. |
| Starting Page | 219 |
| Ending Page | 227 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.nbd.2006.03.002 |
| PubMed reference number | 16690320 |
| Journal | Medline |
| Volume Number | 23 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0969996106000623 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0969996106000623?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.nbd.2006.03.002 |
| Journal | Neurobiology of Disease |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
