Regulation of gene expression and chromatin structure by JIL-1 mediated histone H3 serine10 phosphorylation in Drosophila

Content Provider	Semantic Scholar
Author	Li, Yeran
Copyright Year	2015
Abstract	.......................................................................................................... iii! CHAPTER 1. GENERAL INTRODUCTION .......................................................... 1! Background ........................................................................................................ 1! Research Questions And Significance .............................................................. 6! Thesis Organization ........................................................................................... 7! References ........................................................................................................ 8! CHAPTER 2. LITERATURE REVIEW ................................................................ 11! Chromatin Structure and Organization ............................................................ 11! Chromatin Remodeling .................................................................................... 15! Accelerating Biological Discoveries With Next-Generation Sequencing ......... 23! References ...................................................................................................... 25! CHAPTER 3. DOMAIN REQUIREMENTS OF THE JIL-1 TANDEM KINASE FOR HISTONE H3S10 PHOSPHORYLATION AND CHROMATIN REMODELING IN VIVO ...................................................................................... 35! Summary .......................................................................................................... 35! Introduction ...................................................................................................... 36! Experimental Procedures ................................................................................ 37! Results ............................................................................................................. 42! Discussion ........................................................................................................ 49! References....................................................................................................... 52! Figures ............................................................................................................. 56! Tables .............................................................................................................. 62! CHAPTER 4. GENOME-WIDE ANALYSIS OF REGULATION OF GENE EXPRESSION AND H3K9me2 DISTRIBUTION BY JIL-1 KINASE MEDIATED HISTONE H3S10 PHOSPHORYLATION IN DROSOPHILA .......... 63! Summary .......................................................................................................... 63! Introduction ...................................................................................................... 64! Materials And Methods .................................................................................... 66! Results ............................................................................................................. 71! Discussion ........................................................................................................ 80! Acknowledgements .......................................................................................... 84! References....................................................................................................... 84! Figures ............................................................................................................. 89! Supplemental Materials ................................................................................... 97! CHAPTER 5. GENERAL CONCLUSION ......................................................... 100! General Discussion And Future Directions .................................................... 100! References .................................................................................................... 103! ACKNOWLEDGEMENTS ................................................................................. 104!
File Format	PDF HTM / HTML
DOI	10.31274/etd-180810-3920
Alternate Webpage(s)	https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=5375&context=etd&httpsredir=1&referer=
Alternate Webpage(s)	https://doi.org/10.31274/etd-180810-3920
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article