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Alteration of Sex and Non-Sex Hormones and Distribution Features of Blood ABO System Groups among the Women with Uterine Body Tumors
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nakashidze, Irina Diasamidze, Anzor Baratashvili, Davit Nagervadze, Marina Alibegashvili, Manana Ramishvili, Liana Gordeziani, Manana Khazaradze, Ana Kotrikadze, Nanuli |
| Copyright Year | 2014 |
| Abstract | Objectives: The aim of the investigation was to study the hormonal status (sex hormones: estradiol (E2), progesterone (P), testosterone (T); non-sex gonadotropic hormones-luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) of women with benign and malignant tumors of uterine body in the reproductive, menopause and postmenopause periods. Also the distribution features of the blood ABO system phenotype groups and their link to the development of uterine body tumors have been studied. Methods: The determination of hormones was made by the enzyme analysis method (ELAIZA), provided by the proper ELAIZA kits. For the study of blood ABO system antigens, internationally recognized immunoserology methods were used. Results: Investigations revealed the increased level of E2 and T on the background of the reduced P in the blood of the women with uterine tumors in the reproductive, menopause and post-menopause period. As for gonadotropic hormones, the decreased levels of LH and FSH have also been detected. From the ABO system phenotype groups A(II) group had the highest frequency between the women with malignant uterine tumor in the reproductive age. O (I) phenotype group was the most frequent in case of menopause and post-menopause women with uterine malignant tumors. Conclusions: Hormonal imbalance creates good conditions for the proliferation of uterine tissues and hence causes the development of benign and malignant uterine tumors. The imbalance of the sex steroid and gonadotropic hormones in the blood of post-menopause women indicates on the genotoxic Corresponding author. I. Nakashidze et al. 412 mechanism of cancer development on the background of age-related changes. A(II) group had the highest frequency between the reproductive age women with uterine malignant tumor, while O (I) group was the most frequent in case of menopause and post-menopause patients. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://file.scirp.org/pdf/JCT_2014042311391862.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Glands Body of uterus Body tissue CNS disorder Color gradient Estradiol FastTrack Scripting Host Follicle Stimulating Hormone Gonadal Steroid Hormones Gonadorelin Gonadotropins Hematological Disease Hemolytic disease of fetus OR newborn due to ABO immunization LH (complexity) Lewy Body Disease Malignant Neoplasms Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm Malignant Uterine Corpus Neoplasm Menopause Ovarian Follicle Ovary Patients Phenylephrine Hydrochloride 10 MG Oral Tablet Pituitary Gland Postmenopause Progesterone Reproduction Sex Factors Steroids Stimulation (motivation) Testosterone Uterine Cancer Uterine Corpus Carcinosarcoma Uterine Corpus Neoplasm Uterine Neoplasms |
| Content Type | Text |
| Resource Type | Article |
