NDLI: Clinical management of comorbid bipolar disorder and obsessive-compulsive disorder: A case series.

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Clinical management of comorbid bipolar disorder and obsessive-compulsive disorder: A case series.

Content Provider	Semantic Scholar
Author	Amerio, Andrea Tonna, Matteo Odone, Anna
Copyright Year	2019
Abstract	BACKGROUND Apparent comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is a common condition in psychiatry and it has important nosological and therapeutic implications. Although antidepressantsare the first line treatment for OCD, they can induce mood instability in BD. An optimal treatment approach remains to be defined. METHODS Longitudinal clinical observation of three severe OCD patients who developed a manic episode during treatment with different classes of antidepressants. RESULTS In our cases, three features support the hypothesis of an underlying bipolarity unmasked by the antidepressant used to treat OCD: positive family history for affective disorders, manic switch induced by antidepressantand improvement of affective and obsessive-compulsivesymptoms with mood stabilizers and atypical antipsychotics. CONCLUSIONS Osler's view that medicine should be treatment of diseases, not of symptoms, is consistent with the approach of mood stabilization as a first objective in BD-OCD patients, as opposed to immediate treatment with antidepressants. Only persistent OCD patients should be prescribed antidepressants in as low a dose as feasible.
Starting Page	581
Ending Page	584
Page Count	4
File Format	PDF HTM / HTML
DOI	10.23750/abm.v89i4.7621
PubMed reference number	30657129
Journal	Medline
Volume Number	89
Issue Number	4
Journal	Acta bio-medica : Atenei Parmensis
Alternate Webpage(s)	http://www.mattioli1885journals.com/index.php/actabiomedica/article/download/7621/7512
Alternate Webpage(s)	https://doi.org/10.23750/abm.v89i4.7621
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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