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Prediction of conformational B-cell epitope binding with individual antibodies using phage display peptides
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Chunhua Sun, Bojian Tang, Weina Sun, Pingping Ma, Zhiqiang |
| Copyright Year | 2016 |
| Abstract | B-cell epitopes are a group of residues on the surface of an antigen which invoke strong humoral responses. Predicting epitopes is crucial for disease diagnosis, vaccine design, antibody design and immunological therapy. It is also indispensable for elucidating interactions between antigen and antibody on a molecular level. Since reliable experimental methods are expensive and time consuming, the prediction of B-cell epitope has developed quickly in recent years, but the performance of current prediction methods is far from satisfactory. The results show that our method achieves a sensitivity of 0.59, specificity of 0.64, positive predictive value of 0.45, accuracy of 0.70 and F-measure of 0.49. Compared with the antibody-specific epitope propensity method, the Mapitope method and four other methods, our method could provide reliable, rational results and showed comparable sensitivity, precision and accuracy. In this work, we propose a new conformational B-cell epitope prediction method by binding with individual antibodies using phage display peptides. It is more effective when used to predict the conformational B-cell epitope binding with an individual antibody. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ijcem.com/files/ijcem0017209.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
