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Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pearce, Ian A. Ilango, B. Sarojini Sells, Robert A. Wong, D. |
| Copyright Year | 2000 |
| Abstract | BACKGROUND/AIMS Simultaneous pancreas and kidney transplantation (SPK) has become an important option in selected IDDM patients with end stage renal disease (ESRD). Successful SPK transplants are associated with long term normoglycaemic control and improved quality of life. However, debate still continues on the benefit to patients in terms of stabilisation or amelioration of diabetic retinopathy. The progression of diabetic retinopathy (DR) in a cohort of 20 SPK transplant patients is reported. METHODS All patients were reviewed postoperatively with corrected visual acuity, slit lamp examination, and fundal biomicroscopy. Preoperative data were collected retrospectively and DR was considered unstable if there had been a drop in Snellen acuity greater than three lines or a need for laser photocoagulation or vitrectomy in the 2 years preoperatively. RESULTS 20 patients who received SPK transplants between March 1983 and April 1994 were reviewed (mean age 35.1 years; mean duration of IDDM = 24.6 years). 17 patients still had functioning grafts at a mean follow up of 5.1 years. Nine of these patients had unstable DR before transplantation. Of these, 89% (8/9) had stabilised DR following transplantation with only a single case requiring laser photocoagulation. Of the eight patients that had stable DR before transplantation all had stable DR following transplantation. 41% of cases (7/17) required cataract surgery during the follow up period. CONCLUSIONS Advanced diabetic retinopathy is present in a high proportion of cases managed with SPK transplant as a consequence of the duration of IDDM and the presence of ESRD. More than 90% of cases have stable DR following transplant. |
| Starting Page | 295 |
| Ending Page | 303 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://bjo.bmj.com/content/bjophthalmol/84/7/736.full.pdf |
| PubMed reference number | 10873985v1 |
| Volume Number | 84 |
| Issue Number | 7 |
| Journal | The British journal of ophthalmology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cataract Diabetes Mellitus, Insulin-Dependent Diabetic Retinopathy Eighty Nine Kidney Diseases Kidney Failure, Chronic Kidney Transplantation Pancreas extract Patients Retinal Diseases Slit lamp biomicroscope (physical object) Slit lamp biomicroscopy (procedure) Transplanted tissue Ultrasound Biomicroscopy Unstable Medical Device Problem |
| Content Type | Text |
| Resource Type | Article |
