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Deregulation of RNA Metabolism in Microsatellite Expansion Diseases.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Misra, Chaitali Lin, Feikai Kalsotra, Auinash |
| Copyright Year | 2018 |
| Abstract | RNA metabolism impacts different steps of mRNA life cycle including splicing, polyadenylation, nucleo-cytoplasmic export, translation, and decay. Growing evidence indicates that defects in any of these steps lead to devastating diseases in humans. This chapter reviews the various RNA metabolic mechanisms that are disrupted in Myotonic Dystrophy-a trinucleotide repeat expansion disease-due to dysregulation of RNA-Binding Proteins. We also compare Myotonic Dystrophy to other microsatellite expansion disorders and describe how some of these mechanisms commonly exert direct versus indirect effects toward disease pathologies. |
| Starting Page | 213 |
| Ending Page | 238 |
| Page Count | 26 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.life.illinois.edu/kalsotra/publications/Misra_Adv%20Neurobiol%202018.pdf |
| PubMed reference number | 29916021v1 |
| Alternate Webpage(s) | https://doi.org/10.1007/978-3-319-89689-2_8 |
| DOI | 10.1007/978-3-319-89689-2_8 |
| Journal | Advances in neurobiology |
| Volume Number | 20 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Metabolic Process, Cellular Myotonic Dystrophy Polyadenylation RNA Splicing RNA metabolic process Short Tandem Repeat Trinucleotide Repeat Expansion Trinucleotide Repeats physical hard work |
| Content Type | Text |
| Resource Type | Article |
