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The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Booth, Heather D. E. Hirst, Warren D. Martins, Richard Wade‐ |
| Copyright Year | 2017 |
| Abstract | Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson's disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment. |
| Starting Page | 358 |
| Ending Page | 370 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.tins.2017.04.001 |
| PubMed reference number | 28527591 |
| Journal | Medline |
| Volume Number | 40 |
| Alternate Webpage(s) | https://www.iahe.com/docs/articles/The_Role_of_Astrocyte_Dysfunction_in_ParkinsonYs_Disease_Pathogenesis.pdf |
| Alternate Webpage(s) | http://opdc.medsci.ox.ac.uk/_asset/file/the-role-of-astrocyte-dysfunction-in-parkinson-s-disease-pathogenesis.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0166223617300681 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0166223617300681 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.tins.2017.04.001 |
| Journal | Trends in Neurosciences |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
